Dr. Diego H. Castrillon
 
Diego H. Castrillon is an Associate Professor and the John H. Childers, M.D. Professor of Pathology in the Department of Pathology at UT Southwestern. He was born in San Juan, Puerto Rico and received a bachelor's degree in Life Sciences at M.I.T. and M.D./Ph.D. degrees at UT Southwestern. His doctoral work was on the genetics of infertility, using Drosophila melanogaster as a model system to discover and further study novel genes required for gametogenesis and germline stem cell maintenance. During this time, he identified the diaphanous gene required for germline stem cell maintenance and discovered and named the formin homology domains (FH1 and FH2). Following a residency in Anatomic Pathology at Harvard Medical School and Brigham and Women’s Hospital, he completed a clinical fellowship there in reproductive pathology. As a clinical fellow, he established the utility of p57^KIP2 as a diagnostic marker for hydatidiform mole, a placental maldevelopment and precancer syndrome due to misexpression of imprinted genes, and identified the human VASA gene as a germ cell-specific factor. Dr. Castrillon’s postdoctoral research fellowship in cancer genetics with Dr. Ron DePinho at the Dana Farber Cancer Institute led to the discovery of the pivotal role of the Forkhead transcription factor Foxo3 in the maintenance of oocytes in the mammalian ovary and helped establish the Foxos as tumor suppressors and critical effectors of the PI3K pathway. He is board certified in Anatomic Pathology and a member of the American Society of Clinical Investigators.

Dr. Castrillon serves on the Steering Committees of the Medical Scientist Training Program (MSTP) and the Postdoctoral Training and Cancer Biology Graduate Programs at UT Southwestern, and is the Director of the Investigative Pathology arm of the UTSW Pathology Department.

UT Southwestern Medical Center
Department of Pathology
6000 Harry Hines Boulevard
Dallas TX 75390-9072
Office phone (214) 648-4032
Lab phone (214) 648-4031
Fax (214) 648-7355
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