Principal Investigator

Dr. Diego H. Castrillon Dr. Diego H. Castrillon
I grew up in San Juan, Puerto Rico and Edinburg, Texas and received my undergraduate degree in Life Sciences from M.I.T. in 1987. At M.I.T. / the Whitehead Institute I worked in the laboratory of Dr. Gerry Fink on mobile genetic elements. I then joined the UT Southwestern Medical Scientist Training Program (MSTP), receiving M.D. and Ph.D. degrees in 1996. During my Ph.D. research in the laboratory of Dr. Steven Wasserman, I conducted genome-wide screens for male fertility genes in the model organism Drosophila melanogaster, and described diaphanous, a gene required for germline stem cell maintenance in males. This early work sparked my interests in reproduction, development, and stem cell biology. I returned to Boston to do a residency in Anatomic Pathology at Harvard Medical School, where I specialized in reproductive pathology, and completed a postdoctoral research fellowship in cancer genetics with Dr. Ron DePinho at the Dana Farber Cancer Institute. This work led to the discovery of the pivotal role of the Forkhead transcription factor Foxo3 in the maintenance of oocytes in the mammalian ovary and helped establish the Foxos as tumor suppressors. Our current research is on the connections  between cancer, infertility, and stem cell biology. I am currently an Associate Professor and the John H. Childers, M.D. Professor of Pathology in the Department of Pathology at UT Southwestern. I serve on the Steering Committees of the MSTP, Postdoctoral Training, and Cancer Biology Graduate Programs at UT Southwestern, and as the Director of the Investigative Pathology arm of the UTSW Pathology Department.

UT Southwestern Medical Center
Department of Pathology
6000 Harry Hines Boulevard
Dallas TX 75390-9072
Office phone (214) 648-4032
Lab phone (214) 648-4031
Fax (214) 648-7355